The Pros and Cons of Semaglutide for Weight Loss

Explore the benefits and drawbacks of using Semaglutide for weight loss, and learn if this FDA-approved medication could be the right choice for you.

Semaglutide's Weight Loss Potential

Semaglutide, a medication originally developed for the treatment of type 2 diabetes, has been creating quite a buzz in the weight loss industry. Intriguing results from clinical trials have suggested that this drug may indeed hold significant potential for weight loss.

However, like any medication, semaglutide has its pros and cons that need to be considered. In this article, we will delve into what makes semaglutide a potential game-changer for obesity treatment, and the possible drawbacks that come along with it.

Understanding How Semaglutide Works

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, designed to mimic the functions of the natural hormone GLP-1. This hormone is released in response to food intake and plays a crucial role in managing blood glucose levels. It increases insulin production, slows down digestion, and most importantly for weight loss, reduces appetite.

Semaglutide, marketed under the brand name Ozempic and also available as an oral version called Rybelsus, was approved by the FDA for the treatment of type 2 diabetes in 2017. It’s administered through injections, once a week. While the primary focus of semaglutide is to manage diabetes, weight loss has emerged as a significant side effect.

Southwest Family Medical Semaglutide Program

✓ Telehealth option for convenience

✓ Expert weight loss coordinators 

✓ Simple, easy-to-follow plan

✓ Comprehensive lab panel

Pros of Semaglutide for Weight Loss

  • Proven effectiveness: Clinical trials have demonstrated significant weight loss results with Semaglutide, with participants losing an average of 15% of their body weight.
  • Improved Metabolic Health: Semaglutide doesn’t just support weight loss; it also helps improve overall metabolic health, reducing the risk of cardiovascular disease and improving glycemic control.
  • Appetite suppression: Semaglutide helps control hunger by mimicking the effects of a natural hormone called GLP-1, which regulates appetite.
  • Improved blood sugar control: Semaglutide can also help regulate blood sugar levels, which is particularly beneficial for individuals with type 2 diabetes.
  • Non-surgical option: Semaglutide provides an alternative to more invasive weight loss procedures like bariatric surgery.

Cons of Semaglutide for Weight Loss

  • Potential side effects: Some common side effects of Semaglutide include nausea, diarrhea, constipation, and abdominal pain. These side effects are typically mild and improve over time.
  • Injections: Semaglutide is administered via a once-weekly injection, which may be inconvenient for some individuals.
  • Cost: Semaglutide can be expensive, and insurance coverage varies. It’s important to check with your insurance provider to determine your out-of-pocket costs.
  • Not a standalone solution: Semaglutide should be used in conjunction with a reduced-calorie diet and increased physical activity to achieve the best results.
  • Long-Term Use: As of now, the long-term effects of semaglutide use for weight loss are not well-known. More research is needed to understand the implications of its prolonged use.

Semaglutide and Heart Health Study

Semaglutide Reduces Heart Failure Symptoms

A recent study published in the New England Journal of Medicine found that in patients with obesity and heart failure, semaglutide significantly reduced symptoms like fatigue and shortness of breath. It also led to notable improvements in physical abilities and exercise function.

Semaglutide May Lower Risk of Heart Attack and Stroke

Additional research sponsored by the drug’s manufacturer Novo Nordisk found semaglutide reduced the risk of stroke and heart attack by 20% in people with obesity and a history of cardiovascular disease. While more research is still needed, these findings suggest semaglutide could potentially help lower the risk of adverse cardiovascular events in certain high-risk populations.

Potential as Preventive Medicine

If proven effective for cardiovascular protection, semaglutide could become an important preventive medicine for select patients with obesity, diabetes, and heart disease risk factors. However, expanded use of the drug for heart health may depend on it becoming more accessible and affordable.

Is Semaglutide Right for You?

 If you have been struggling with obesity or are overweight and have not found success with lifestyle modifications alone, Semaglutide may provide the additional support you need.

However, it’s crucial to understand that some of the weight loss associated with Semaglutide comes from a decrease in lean mass, which includes muscle and water weight. This loss of lean mass can potentially lower your basal metabolic rate (BMR), the rate at which your body uses energy when at rest. Lower BMR may make it harder to maintain weight loss in the long term. Thus, it’s important to weigh the potential benefits of weight loss against the potential risks of losing lean mass.

Semaglutide may also reduce appetite significantly, which can help with weight loss but may also lead to nutritional deficiencies if not carefully managed. It’s essential to maintain a balanced diet while using this medication to ensure your body gets the nutrients it needs.

Southwest Family Medical

Southwest Family Medical Doctors and Staff


(480) 404-1776


2919 S Ellsworth Rd #103-B
Mesa, AZ 85212

Let Us Know You're Interested in Our Semaglutide Program

Schedule An Appointment